Project Name
EURICA: The epidemiology of urinary tract infection (UTI) in children with acute illness in primary care.


National Assembly for Wales

Principal Investigator
Prof Chris Butler

C.C. Butler, C. Powell, K. Hood, A. Edwards, N. Topley, V. O'Donnell, R. Howe.

Type of study
Observational Pilot Study

UTI in children can lead to serious complications. The highest risk is in young children, but UTI is difficult to diagnose in this group as symptoms are often non-specific. The true prevalence of UTI in ill children presenting in primary care is not known as no studies have systematically sampled urine from this group. However, previous studies have suggested that many cases are missed. The early diagnosis and prompt treatment of UTI will reduce suffering from the acute illness and may also prevent serious complications such as hypertension and renal failure. A high level of suspicion, with increased, targeted, urine sampling, would be needed in order to improve diagnosis of UTI, a policy supported by the recent NICE guidelines. To achieve increased diagnostic rates, primary care clinicians would need to change their sampling behaviour. Rightly, clinicians will only do this if there is evidence to support the contention that UTI is sufficiently common among acutely unwell children consulting in general practice to warrant additional testing. Increasing testing without such justification is likely to unnecessarily increase laboratory costs, consultation length and probably frequency in primary care. Current good quality evidence about the frequency, severity, outcomes and risk factors for complications of childhood UTI is needed in the GP setting. EURICA aims to determine the prevalence of UTI in children under the age of five presenting to primary care with an acute illness.

Group role / contribution
WSPCR supported

Start date
April 2008

End date
May 2010